WP2 - Interactions of the influenza virus RNA polymerase with host factors

Partners involved:
N° 5, Dr. Ervin Fodor (WP Leader)
N° 1, Prof. Otto Haller
N° 6, Dr. Nadia Naffakh

The aim of WP2 is to identify crucial host factors that interact with the influenza virus RNA polymerase complex. There is increasing evidence that the RNA polymerase is a crucial determinant of viral host range and pathogenicity, which suggests that there is a differential interaction between host factors and RNA polymerases in different hosts. Our aim is to identify these host factors and elucidate their role in the processes of viral RNA synthesis.